The odds on making it into the next round if you lose at home are dramatically slashed and Celtic boss Ronny Deila will be well aware of that.
He will also know that Inter Milan have come into the tie with all guns blazing and will be looking to take at least an away goal back to the San Siro with them.
Despite those lofty ambitions, we think that Celtic can beat Inter if they keep these five things in mind.
Click on manager Ronny Deila to see how we think the Hoops can beat their opponents.
Celtic fans. How would you set the team up to face Inter? What result do you want to take back to the San Siro? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.