With only two points separating the sides at the minute, both clubs will want to secure the win and ensure that they get a massive boost ahead of a huge few weeks for all the clubs fighting for Champions League football next season.
With Southampton and Manchester United both looking like good candidates for the third and fourth spot, winning is more important than ever for the bitter rivals and with that in mind, we have taken a look at five Spurs players who could help the home side make that happen.
Click on Christian Eriksen to see who else we think could well take the three points for Spurs.
Spurs fans. What do you think the score will be? Can you get a real hold on a run at the top four if you beat Arsenal? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.