Not only do they now have issues with their defence, but their midfield and attack are taking a couple of hits and they have even had to worry about their star man, goalkeeper David De Gea who might not be totally fit for the crunch clash.
Now before Louis van Gaal decides that United may as well write the next couple of weeks off, we think that there are in fact a couple of ways to get around it and we have put our heads together and come up with five ways they can still get maximum points in their next few games.
Click on Wayne Rooney to see just how we think United can overcome their injury issues.
Manchester United fans. Do you think your injury issues will have a big impact on the next couple of weeks? Let us know your thoughts below or tweet us @LaFootyettes.