But it does not stop the La Liga side suffering more than most when it comes to the curse of the international break – or as some call it, FIFA Virus.
Los Blancos rarely come out of an international break unscathed and this time around was no different.
Luka Modric now faces a spell of at least three months on the sidelines and given his now vital importance to the club, it has given manager Carlo Ancelotti a huge headache.
Modric may have initially struggled after his move from north London to Madrid – and was even voted one of the two worst signings of that transfer window along with Barcelona buy Alex Song.
Whilst Song is now on loan at West Ham United after failing to impress at the Camp Nou, Modric has become a Real Madrid star. He is simply magnificent and despite having a host of partners in the last couple of seasons, with Sami Khedira, Asier Illarramendi, Xabi Alonso and Toni Kroos all featuring at times, he has not faltered.
He is the puppeteer of the Real Madrid side and was vital in their quest for the Champions League last season.
Now however he will be missing for a considerable amount of time. Fortunately for Ancelotti, who has the best squad in world football at the minute, certainly in terms of his attacking options, he has someone waiting in the wings.
Isco, who can play in any number of attacking positions, has been excellent recently and capped a great week off with a wonder goal for Spain in their Euro 2016 qualifier to open the scoring up and help La Roja on their way to three points.
Life at Madrid for Isco did not initially look like going to plan and having a dog named after Lionel Messi became the least of his worries.
It actually looked like Isco was going to be sold or sent out on loan at one point – especially with the purchase of James Rodriguez in the summer, but an injury to Gareth Bale allowed him the chance to shine. And he did. Very brightly indeed.
In fact, it left Ancelotti with a selection dilemma once Bale regained fitness.
Now however the Italian has to explore the possibility of either rejigging the starting formation and having Kroos and Khedira as holding midfielders or simply just replacing Modric with Isco.
The Spaniard is multitalented and can easily play the role of puppeteer playmaker and creative star – Ancelotti just needs to give him the chance to do so.
Real Madrid fans. Just how highly do you rate Isco? Is he someone you think could really elevate you to the next level? Let us know your thoughts below or tweet us @LaFootyettes.