Beating Chelsea and becoming the only side to do so in the Premier League at that point in the season but losing to rivals Sunderland and being hammered by Manchester City have all been par for the course, so predicting the final score against Manchester United is a bit of a job.
Given they have home advantage and the Toon Army backing them, John Carver and his players will want to at least put on a good show and give Manchester United boss Louis van Gaal something to think about and here is why we think Newcastle may actually be able to do even more than that.
Click on the Magpies themselves to see why we think they can pull off a shock result.
Newcastle fans. What are your final score predictions? Will this be Manchester City all over again? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.