The young centre back has been nothing but impressive since winning his place back in the starting XI and will have to be on top form against the Italians.
Jan Vertonghen is a tried and tested partner for nights like these and will have to help his young partner when he can.
Dier has shown against both Liverpool and Arsenal that he can cut it with the big boys and will once again want to rise to the occasion when facing the likes of Gomez and Mohamed Salah.