Their biggest weakness being losing Juan Cuadrado in January to Chelsea.
In 2013/14 season, Cuadrado scored 11 goals in 32 league appearances, as well as three goals in eight appearances in Europe for Fiorentina, and as of yet they have not really managed to replace the goals despite Mohamed Salah going in the opposite direction.
If Spurs can expose this weakness and use it to their advantage, they can progress in Europe.