Liverpool are desperate to get back into the top four and given they cannot now qualify for the Champions League any other way after being knocked out by Besiktas, it is this or bust for the Reds.
City meanwhile will take the opportunity to send out a message to Chelsea – who they can close the gap on to two points – and show that an away trip to Anfield does not hold any fear for them.
With that in mind, we have taken a look at five reasons Liverpool can beat City.
Click on Brendan Rodgers to see why we think Liverpool can and will beat Manchester City.
Liverpool fans. Are you optimistic about your chances against City? Can you keep that top four fight open? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.