That is undoubtedly a match up of European giants and with Inter Milan holding on to the hopes of reasserting some form of dominance on the European stage, Celtic will have their work cut out for them.
Confidence is high in the Hoops camp and it could not be more different to what Inter are facing with Roberto Mancini taking over a broken side who are languishing in Serie A and are finding their fans increasingly irate.
We think that Ronny Deila is right to be cautious about the tie, but the quiet optimism their fans have adopted is right – and here are five reasons the SPL side can progress to the next round.
Click on Ronny Deila to see just why we think his side can come out on top in Europe.
Celtic fans. Do you think that you can overcome Inter over two legs? Who will be your key players? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.