Before they can begin to think about lifting the trophy, they will have to make sure that they get past Besiktas, which will be no easy task given the Turkish side are no pushovers and have Demba Ba in their ranks.
Liverpool are sweating on the fitness of Raheem Sterling and are without skipper Steven Gerrard, suspended Lazar Markovic and injured Lucas – meaning their remaining players will have to be at the top of their game.
With that in mind, we have taken a look at five Liverpool players who have to perform in order for the Reds to take a decent lead into the away leg.
Click on Jordan Henderson to see who has to play well for the Reds to come away with the result.
Liverpool fans. Are you hopeful you can get a first leg win? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.