Both sides are desperate for not only three points but also the pride of the city and with the January transfer window now closed, all eyes are on the rest of the season and just what each side expects.
The fans want a hotly contested game, preferably with plenty of passion and goals – and with Liverpool coming through their FA Cup tie against Bolton Wanderers, the Toffees will be looking to capitalise on their freshness and come away with all three points and show their visitors that Liverpool is blue.
With that in mind, we have taken a look at just who could help do that.
Click on Ross Barkley to see who else we think will be crucial against the Reds.
Everton fans. Who do you think will be vital in landing you the three points on the weekend? Let us know your thoughts below, become a guest blogger or tweet us @LaFootyettes.